The Truth of Pills containing extract of fish cartilage (Imedeen)

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The largest and most reliable study found that fish-extract pills were no better than a dummy treatment. There was no effect on people's wrinkles even after three months of treatment. One study did suggest that fish-extract pills might help with fine wrinkles, but it only looked at 30 women, which makes the results less reliable.

In one study, about a quarter of the women taking fish-extract pills got some side effects, including spots, greasy skin or weight gain. But roughly the same number of women taking a placebo got side effects too, so we can't say whether the treatment caused these problems.